Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | CCR4 | P51679 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953370 | 0.89 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL22733326 | 0.82 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL6888225 | 0.81 | SRC (0.53) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL11748869 | 0.78 | CA1 (0.61) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL4955063 | 0.78 | CCR4 (0.52) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL16697876 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL38652222 | 0.77 | NQO1 (0.69) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL15842470 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL1850238 | 0.76 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDGAAPOLB | |
| SCHEMBL28497661 | 0.76 | NQO1 (0.65) | KDM4EALDH1A1HPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080032917-A1 | FLAVIVIRUS PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2008-02-07 | — | — | US | claimed |
| WO-2006014232-A2 | DENGUE PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2006-02-09 | — | — | WO | claimed |
| US-20050222383-A1 | Prostasin substrates and inhibitors | IRM LLC (BM) | 2005-10-06 | — | — | US | claimed |
| WO-2005076886-A2 | PROSTASIN SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | claimed |
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | claimed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | claimed |
| US-20190144912-A1 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | SCRIPPS RESEARCH INST (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3344043-A2 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | The Scripps Research Institute (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017040762-A2 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | disclosed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009911-A1 | Hepsin substrates and prodrugs | HPN, SPR, TMPRSS15 | KDM4E 4130/4885ALDH1A1 2407/4885HPGD 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.