Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489804 | 0.79 | — | — | |
| SCHEMBL489803 | 0.79 | — | — | |
| SCHEMBL9869901 | 0.79 | — | — | |
| SCHEMBL2637647 | 0.79 | — | — | |
| SCHEMBL28638484 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRLCKPPARDZDHHC20 | |
| SCHEMBL8308905 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRLCKPPARDZDHHC20 | |
| SCHEMBL310533 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL18580855 | 0.77 | RNPEP (0.48) | ALDH1A1TSHRLCKPPARDZDHHC20 | |
| SCHEMBL27949976 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRLCKPPARDZDHHC20 | |
| SCHEMBL27533786 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354905-B2 | Prodrugs of thrombin inhibitors | ASTRAZENECA AB (SE) | 2008-04-08 | — | — | US | disclosed |
| US-7144902-B1 | Prodrugs of thrombin inhibitors | ABBOTT GMBH & CO. KG (DE) | 2006-12-05 | — | — | US | disclosed |
| EP-1533318-A1 | Prodrugs of thrombin inhibitors | AstraZeneca AB (SE) | 2005-05-25 | — | — | EP | disclosed |
| EP-0869966-B1 | PRODRUGS OF THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| US-20040162410-A1 | Prodrugs of thrombin inhibitors | ASTRAZENECA AB (SE) | 2004-08-19 | — | — | US | disclosed |
| US-20020142968-A1 | Prodrugs of thrombin inhibitors | ASTRAZENECA AB | 2002-10-03 | — | — | US | disclosed |
| EP-0995755-B1 | Prodrugs of Thrombin inhibitors | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-6262028-B1 | CONTAINING OXY-SUBSTITUTED AMIDINOBENZYL DERIVATIVES OF DIPEPTIDES FROM CYCLOHEXYLGLYCINE AND AZETIDINE-2-CARBOXYLIC ACID; ximelagatran | ASTRAZENECA AB (SE) | 2001-07-17 | — | — | US | disclosed |
| EP-0995755-A1 | Prodrugs of Thrombin inhibitors | Astra Aktiebolag (SE) | 2000-04-26 | — | — | EP | disclosed |
| US-5965692-A | ANTICOAGULANTS FOR TREATMENT OF THROMOBOSIS AND HYPERCOAGULABILITY IN BLOOD AND TISSUES | ASTRA AB (SE) | 1999-10-12 | — | — | US | disclosed |
| EP-0869966-A1 | PRODRUGS OF THROMBIN INHIBITORS | Astra Aktiebolag (SE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023499-A1 | PRODRUGS OF THROMBIN INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1997-07-03 | — | — | WO | disclosed |