Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060435 | 0.93 | CRBN (0.56) | NPC1RAB9AGAACRBNALDH1A1 | |
| Water SCHEMBL28110279 | 0.92 | CRBN (0.55) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL28510668 | 0.87 | CRBN (0.51) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL2771765 | 0.87 | CRBN (0.51) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL2771766 | 0.87 | CRBN (0.51) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL22720116 | 0.87 | ALDH1A1 (0.66) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL13161898 | 0.87 | ALDH1A1 (0.61) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL22720137 | 0.86 | RAB9A (0.59) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL13634186 | 0.86 | RAB9A (0.59) | NPC1RAB9AGAACRBNALDH1A1 | |
| SCHEMBL29229446 | 0.85 | ALDH1A1 (0.69) | NPC1RAB9AGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |