Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GSTA2 | P09210 | 1/20 | 0.35 |
| ▸ | GSTM1 | P09488 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 6/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960368 | 0.80 | CNR2 (0.40) | CYP3A4ALDH1A1SMN1; SMN2ALOX15ALOX12 | |
| SCHEMBL14879974 | 0.79 | AKR1B1 (0.48) | ALDH1A1HTTLMNAHPGD | |
| SCHEMBL2868883 | 0.78 | TSHR (0.38) | ALDH1A1SMN1; SMN2ALOX15ALOX12HTT | |
| SCHEMBL1165753 | 0.77 | TSHR (0.36) | ALDH1A1SMN1; SMN2ALOX15ALOX12HTT | |
| SCHEMBL1314145 | 0.75 | ALDH1A1 (0.57) | CYP3A4ALDH1A1SMN1; SMN2ALOX12HTT | |
| SCHEMBL30608424 | 0.75 | ALDH1A1 (0.57) | CYP3A4ALDH1A1SMN1; SMN2ALOX12HTT | |
| SCHEMBL2466231 | 0.74 | NPC1 (0.58) | ALDH1A1SMN1; SMN2MAOBHPGDNPC1 | |
| SCHEMBL22924626 | 0.73 | TDP1 (0.43) | ALDH1A1SMN1; SMN2HTTLMNAHPGD | |
| SCHEMBL14898315 | 0.73 | L3MBTL1 (0.38) | CYP3A4ALDH1A1SMN1; SMN2ALOX15ALOX12 | |
| SCHEMBL20187376 | 0.73 | LTA4H (0.45) | ALDH1A1GSTP1LMNAMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080274947-A1 | Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-20080274947-A1 | Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-20080274947-A1 | Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| WO-2007059871-A1 | HYDROXY-SUBSTITUTED DIPHENYLAZETIDINONES FOR THE TREATMENT OF HYPERLIPIDAEMIA | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274947-A1 | Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia | CYP46A1, GPR119, DHCR7 | CYP3A4 311/4885ALDH1A1 479/4885IDH1 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.