SCHEMBL4956594

SCHEMBL4956594

O=c1[nH]sc2ccc[c]c12

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
LMNA P02545 2/20 0.48
MAPT P10636 2/20 0.48
KDM4E B2RXH2 1/20 0.48
DDAH1 O94760 1/20 0.48
CASP3 P42574 1/20 0.48
HTT P42858 1/20 0.48
CACNA1B Q00975 1/20 0.48
APBA1 Q02410 1/20 0.48
POLB P06746 1/20 0.35
MAOA P21397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30205726 0.66 ALDH1A1 (1.00) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL29356731 0.66 ALDH1A1 (1.00) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL26078 0.66 ALDH1A1 (1.00) ALDH1A1LMNAMAPTKDM4EDDAH1
Potassium SCHEMBL29386009 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
Water SCHEMBL28841499 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL19019940 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL141587 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL10354185 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
Water SCHEMBL17558061 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1
SCHEMBL2261751 0.64 ALDH1A1 (0.95) ALDH1A1LMNAMAPTKDM4EDDAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773281-B1 Preparations for production of stabilized coolantiubricants SCHUELKE & MAYR GMBH (DE) 2005-10-19 EP claimed
US-20050065199-A1 Low-salt or salt-free microbicidal composition based on isothiazolone derivatives and pyrion disulphide AIR LIQUIDE SANTE (INTERNATIONAL) (FR) 2005-03-24 US claimed
EP-1514473-A1 Low-salt or salt-free microbicidal composition based on isothiazolone derivatives and pyrion disulphide Air Liquide Santé (International) (FR) 2005-03-16 EP claimed
EP-0201735-B1 N-INDOLYLETHYL SULFON AMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE BAYER AG (DE) 1990-09-12 EP claimed
EP-0201735-A1 N-indolylethyl sulfon amides, process for their preparation and their use BAYER AG (DE) 1986-11-20 EP claimed
US-20190307726-A1 PHARMACEUTICAL FORMULATIONS MOLECULAR DEFENSES CORP (US) 2019-10-10 US disclosed
US-9840092-B2 Image forming apparatus using a pre-processing liquid and a post-processing liquid, and an image forming method using a pre-processing liquid and a post-processing liquid RICOH COMPANY, LTD. (JP) 2017-12-12 US disclosed
WO-2017091737-A1 PHARMACEUTICAL FORMULATIONS Molecular Defenses Corporation (US) 2017-06-01 WO disclosed
US-20160136975-A1 IMAGE FORMING APPARATUS USING A PRE-PROCESSING LIQUID AND A POST-PROCESSING LIQUID, AND IMAGE FORMING METHOD USING A PRE-PROCESSING LIQUID AND A POST-PROCESSING LIQUID YASU KAZUKI (JP) 2016-05-19 US disclosed
US-9272539-B2 Image forming apparatus using a pre-processing liquid and a post-processing liquid, and an image forming method using a pre-processing liquid and a post-processing liquid RICOH COMPANY, LTD. (JP) 2016-03-01 US disclosed
US-8967753-B2 Image forming apparatus using a pre-processing liquid and drying a printing medium, and image forming method using a pre-processing liquid and drying the printing medium RICOH COMPANY, LTD. (JP) 2015-03-03 US disclosed
US-20130293617-A1 IMAGE FORMING APPARATUS USING A PRE-PROCESSING LIQUID AND DRYING A PRINTING MEDIUM, AND IMAGE FORMING METHOD USING A PRE-PROCESSING LIQUID AND DRYING THE PRINTING MEDIUM SCREEN Holdings Co., Ltd. (JP) 2013-11-07 US disclosed
US-4774240-A ANTICOAGULANTS, ANTIALLERGENS, ANTIHISTAMINES BAYER AKTIENGESELLSCHAFT (DE) 1988-09-27 US disclosed
EP-0201735-A1 N-indolylethyl sulfon amides, process for their preparation and their use BAYER AG (DE) 1986-11-20 EP disclosed
US-4350702-A 2-SUBSTITUTED BENZISOTHIAZOLONES BEECHAM GROUP LIMITED (GB) 1982-09-21 US disclosed
US-4243669-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1981-01-06 US disclosed
US-4212872-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1980-07-15 US disclosed
US-4212979-A ANTITHROMOGENIC BEECHAM GROUP LIMITED (GB) 1980-07-15 US disclosed
EP-0001503-A1 Antithrombotic compositions containing benzisothiazolones BEECHAM GROUP PLC (GB) 1979-04-18 EP disclosed
US-4113728-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1978-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050065199-A1 Low-salt or salt-free microbicidal composition based on isothiazolone derivatives and pyrion disulphide NOX5, NOX4, NOX1 ALDH1A1 1188/4885LMNA 4743/4885MAPT 3396/4885
US-20190307726-A1 PHARMACEUTICAL FORMULATIONS GSS, GSR, MGST3 ALDH1A1 2716/4885LMNA 4432/4885MAPT 3909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.