Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.88 |
| ▸ | TP53 | P04637 | 3/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.88 |
| ▸ | CASP1 | P29466 | 3/20 | 0.88 |
| ▸ | CASP7 | P55210 | 3/20 | 0.88 |
| ▸ | HBB | P68871 | 3/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | TSHR | P16473 | 2/20 | 0.88 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.88 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.88 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.88 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.88 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.88 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.88 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362529 | 0.95 | USP2 (0.83) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL29717736 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL17704776 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL29363141 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL1817364 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL20205 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL19225 | 0.94 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL162379 | 0.93 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL15061349 | 0.93 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 | |
| Quinacrine SCHEMBL33693 | 0.93 | USP2 (1.00) | USP2TP53CYP3A4CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | disclosed |
| WO-2007040469-A2 | CHLOROQUINE COUPLED COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | KOSAK KEN M (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | KOSAK KENNETH M | 2007-03-15 | — | — | US | disclosed |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | KOSAK KENNETH M | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | CHMP4B, CTSA, CLTA | USP2 1617/4885TP53 2795/4885CYP3A4 2329/4885 |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | CHMP4B, CTSA, CLTA | USP2 1497/4885TP53 2605/4885CYP3A4 2799/4885 |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | TLR9, TLR3, EXOSC5 | USP2 2326/4885TP53 1581/4885CYP3A4 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.