Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.35 |
| ▸ | GABRD | O14764 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.35 |
| ▸ | GABRE | P78334 | 3/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.35 |
| ▸ | HAAO | P46952 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937360 | 0.79 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28360290 | 0.75 | CYP1A2 (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27893912 | 0.72 | GABRP (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2227278 | 0.72 | ALDH1A1 (0.55) | MYCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2064870 | 0.69 | ALDH1A1 (0.57) | MYCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL600023 | 0.69 | HMGB1 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2382535 | 0.68 | LOXL2 (0.40) | KDM4EALDH1A1HPGDHSD17B10CD274 | |
| SCHEMBL27669069 | 0.68 | HMGB1 (0.55) | MYCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29850850 | 0.67 | HAAO (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28733643 | 0.67 | GABRP (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7316999-B2 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2008-01-08 | — | — | US | disclosed |
| EP-1290024-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-20020028767-A1 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2002-03-07 | — | — | US | disclosed |
| WO-2001092334-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028767-A1 | Glucose dependent release of insulin from glucose sensing insulin derivatives | GPR119, IRS1, IAPP | GABRP 1450/4885GABRD 1861/4885GABRA1 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.