Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.65 |
| ▸ | GRK5 | P34947 | 1/20 | 0.65 |
| ▸ | CDK8 | P49336 | 1/20 | 0.65 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | UBE2M | P61081 | 1/20 | 0.57 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29783820 | 1.00 | SIGMAR1 (0.67) | SIGMAR1S1PR5S1PR1GRK5CDK8 | |
| SCHEMBL31414613 | 0.88 | SIGMAR1 (0.63) | SIGMAR1S1PR5S1PR1GRK5CDK8 | |
| SCHEMBL4000036 | 0.84 | S1PR5 (0.58) | SIGMAR1S1PR5S1PR1GRK5CDK8 | |
| SCHEMBL24529849 | 0.83 | SIGMAR1 (0.62) | SIGMAR1S1PR5KDM4EALDH1A1FAAH | |
| SCHEMBL17099355 | 0.83 | FAAH (0.59) | SIGMAR1S1PR5S1PR1GRK5CDK8 | |
| SCHEMBL1519149 | 0.82 | SIGMAR1 (0.65) | SIGMAR1KDM4EALDH1A1FAAH | |
| SCHEMBL18657812 | 0.82 | SIGMAR1 (0.65) | SIGMAR1KDM4EUBE2MDCUN1D1 | |
| SCHEMBL171786 | 0.81 | KDM4E (0.65) | SIGMAR1KDM4EALDH1A1GAALMNA | |
| SCHEMBL2929974 | 0.81 | FAAH (0.72) | SIGMAR1S1PR5S1PR1GRK5CDK8 | |
| SCHEMBL3938442 | 0.81 | CHRM4 (0.66) | SIGMAR1DRD4KCNH2CACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407977-B2 | Substituted N-acyl-2-aminothiazoles | HOFFMAN-LA ROCHE INC. (US) | 2008-08-05 | — | — | US | claimed |
| CN-1993336-A | Substituted n-acyl-2-aminothiazoles | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | CN | claimed |
| US-20060030589-A1 | Substituted N-acyl-2-aminothiazoles | HOFFMANN-LA ROCHE INC. | 2006-02-09 | — | — | US | claimed |
| US-7407977-B2 | Substituted N-acyl-2-aminothiazoles | HOFFMAN-LA ROCHE INC. (US) | 2008-08-05 | — | — | US | disclosed |
| CN-1993336-A | Substituted n-acyl-2-aminothiazoles | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | CN | disclosed |
| EP-1791822-A1 | SUBSTITUTED N-ACYL-2-AMINOTHIAZOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| US-20060030589-A1 | Substituted N-acyl-2-aminothiazoles | HOFFMANN-LA ROCHE INC. | 2006-02-09 | — | — | US | disclosed |
| WO-2006013054-A1 | SUBSTITUTED N-ACYL-2-AMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030589-A1 | Substituted N-acyl-2-aminothiazoles | SLC5A2, ABAT, AGTR2 | SIGMAR1 3791/4885S1PR5 1529/4885S1PR1 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.