Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103381 | 0.91 | ABCC1 (0.63) | ABCC1PTPN2PTPN1PTPN6CDC25B | |
| SCHEMBL4959294 | 0.85 | ALDH1A1 (0.63) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL17817419 | 0.80 | ALDH1A1 (0.60) | PTPN2PTPN1CDC25BMEN1KMT2A | |
| SCHEMBL14609709 | 0.79 | PTPN2 (0.64) | ABCC1PTPN2PTPN1MEN1KMT2A | |
| SCHEMBL28835142 | 0.78 | ABCC1 (0.55) | ABCC1PTPN2PTPN1PTPN6CDC25B | |
| SCHEMBL24104683 | 0.78 | MAPK8 (0.62) | PTPN2PTPN1CDC25BMEN1KMT2A | |
| SCHEMBL7471912 | 0.78 | TSHR (0.49) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL28804997 | 0.78 | PTPN2 (0.62) | ABCC1PTPN2PTPN1MEN1KMT2A | |
| SCHEMBL2255525 | 0.77 | ABCC1 (0.57) | ABCC1PTPN2PTPN1MEN1KMT2A | |
| SCHEMBL10037239 | 0.77 | ABCC1 (0.57) | ABCC1PTPN2PTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |