Difluprednate

SCHEMBL4959751

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nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Difluprednate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.60

▸	LMNA	P02545	9/20	0.66

▸	HIF1A	Q16665	7/20	0.66

▸	NPSR1	Q6W5P4	3/20	0.66

▸	PGR	P06401	7/20	0.60

▸	AR	P10275	3/20	0.60

▸	ALDH1A1	P00352	1/20	0.60

▸	MEN1	O00255	1/20	0.60

▸	KMT2A	Q03164	1/20	0.60

▸	CYP3A4	P08684	6/20	0.57

▸	HSD17B10	Q99714	3/20	0.57

▸	KDM4E	B2RXH2	2/20	0.57

▸	MAPT	P10636	2/20	0.57

▸	TDP1	Q9NUW8	1/20	0.57

▸	MAPK1	P28482	1/20	0.57

▸	ABCB11	O95342	2/20	0.52

▸	CYP2C19	P33261	1/20	0.52

▸	HTR1A	P08908	1/20	0.52

▸	ADRA2A	P08913	1/20	0.52

▸	ADRA1A	P35348	1/20	0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinonide SCHEMBL616754	0.90	NR3C1 (0.74)	LMNAHIF1ANPSR1NR3C1PGR
Fluocinonide SCHEMBL15568196	0.87	HIF1A (0.58)	LMNAHIF1ANPSR1NR3C1PGR
Fluocinolone Acetonide SCHEMBL8450831	0.86	NR3C1 (0.77)	LMNAHIF1ANPSR1NR3C1PGR
Amcinonide SCHEMBL22684943	0.85	NR3C1 (0.64)	LMNAHIF1ANPSR1NR3C1PGR
Difluprednate SCHEMBL28142821	0.85	HIF1A (0.71)	LMNAHIF1ANPSR1NR3C1PGR
Difluprednate SCHEMBL13724380	0.85	HIF1A (0.71)	LMNAHIF1ANPSR1NR3C1PGR
Prednicarbate SCHEMBL6470591	0.85	NR3C1 (0.57)	LMNAHIF1ANPSR1NR3C1PGR
Fluocinolone Acetonide SCHEMBL15568127	0.83	HIF1A (0.57)	LMNAHIF1ANPSR1NR3C1PGR
Betamethasone Valerate SCHEMBL8449742	0.83	NR3C1 (0.64)	LMNAHIF1ANR3C1PGRAR
Difluprednate SCHEMBL23343379	0.81	HIF1A (1.00)	LMNAHIF1ANPSR1NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9216106-B2	Device and method for the delivery of drugs for the treatment of posterior segment disease	DIRECTCONTACT LLC (US)	2015-12-22	—	—	US	disclosed
US-20080318843-A1	Device and Method for the Delivery of Drugs for the Treatment of Posterior Segment Disease	DIRECTCONTACT LLC (US)	2008-12-25	—	—	US	disclosed