Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 4/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985307 | 0.83 | TARBP2 (0.41) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| SCHEMBL361590 | 0.80 | ALDH1A1 (0.50) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| SCHEMBL4961136 | 0.78 | ALDH1A1 (0.47) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| Hydrochloric Acid SCHEMBL11140661 | 0.76 | ALDH1A1 (0.46) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| SCHEMBL17646773 | 0.75 | ALDH1A1 (0.46) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| SCHEMBL20378343 | 0.74 | KDM4E (0.42) | ALDH1A1CYP1A2FBP1KDM4EHPGD | |
| SCHEMBL4958502 | 0.74 | ALDH1A1 (0.44) | ALDH1A1CYP1A2FBP1ADORA3ADORA2A | |
| SCHEMBL28561959 | 0.73 | KDM4E (0.41) | ALDH1A1CYP1A2KDM4EHPGDGAA | |
| SCHEMBL4963472 | 0.72 | CSNK1D (0.43) | ALDH1A1CYP1A2KDM4EHPGDTARBP2 | |
| SCHEMBL2843820 | 0.72 | ALDH1A1 (0.59) | ALDH1A1CYP1A2ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | claimed |
| EP-1966176-A1 | HETEROCYCLIC GABA-B MODULATORS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | claimed |
| WO-2007073296-A1 | HETEROCYCLIC GABA-B MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | claimed |
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007073296-A1 | HETEROCYCLIC GABA-B MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312291-A1 | Heterocyclic Gaba-b Modulators | GABBR1, GABBR2, GABRB1 | ALDH1A1 1429/4885CYP1A2 599/4885FBP1 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.