Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960052 | 0.83 | ALDH1A1 (0.45) | TARBP2ALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL20378343 | 0.75 | KDM4E (0.42) | TARBP2ALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL4970342 | 0.75 | TARBP2 (0.40) | TARBP2ALDH1A1CYP1A2MAPTPDCD4 | |
| SCHEMBL28561959 | 0.74 | KDM4E (0.41) | TARBP2ALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL18018776 | 0.70 | CTSK (0.45) | TARBP2ALDH1A1CYP1A2MAPTPDCD4 | |
| SCHEMBL18018717 | 0.69 | MMP2 (0.48) | ALDH1A1CYP1A2MAPTKDM4EHPGD | |
| SCHEMBL22213904 | 0.68 | HTT (0.47) | TARBP2ALDH1A1CYP1A2MAPTKDM4E | |
| SCHEMBL6506484 | 0.68 | NPSR1 (0.47) | TARBP2ALDH1A1MAPTPDCD4KDM4E | |
| SCHEMBL24351435 | 0.68 | NPC1 (0.46) | ALDH1A1CYP1A2GAA | |
| SCHEMBL13400747 | 0.68 | CYP1A2 (0.49) | ALDH1A1CYP1A2MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966176-A1 | HETEROCYCLIC GABA-B MODULATORS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007073296-A1 | HETEROCYCLIC GABA-B MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |