Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | USP5 | P45974 | 6/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26213661 | 0.79 | HSD11B1 (0.52) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL4960919 | 0.79 | CA12 (0.54) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL27582496 | 0.78 | MMP2 (0.52) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL9320214 | 0.77 | NPY5R (0.58) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL21033833 | 0.77 | HSD11B1 (0.51) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL4964431 | 0.77 | MMP2 (0.54) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL31527727 | 0.77 | CA12 (0.56) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL26213675 | 0.77 | USP30 (0.51) | USP30MMP2MMP13HSD11B1USP5 | |
| SCHEMBL1983277 | 0.72 | HPGD (0.63) | TSHRALDH1A1KMT2A | |
| SCHEMBL30683332 | 0.71 | KDM1A (0.51) | USP30MMP2MMP13HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881959-A1 | PROCESS FOR PREPARATION OF SULFAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006127184-A1 | PROCESS FOR PREPARATION OF SULFAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-30 | — | — | WO | disclosed |