Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959701 | 0.85 | LMNA (0.47) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL4964973 | 0.83 | LMNA (0.47) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL4962537 | 0.76 | LMNA (0.44) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL1236446 | 0.74 | PIK3CG (0.50) | PIK3CDPIK3CGPIK3C3 | |
| SCHEMBL4965155 | 0.70 | OGA (0.43) | LMNAMAPTMEN1KMT2APIK3CG | |
| SCHEMBL4973460 | 0.68 | LMNA (0.47) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL1235107 | 0.65 | PIK3CG (0.48) | PIK3CDPIK3CGPIK3C3 | |
| SCHEMBL12523827 | 0.65 | LMNA (0.55) | LMNAMAPTMEN1KMT2ACDK2 | |
| SCHEMBL1236704 | 0.65 | PIK3CG (0.46) | POLBPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL4672859 | 0.63 | LMNA (0.53) | LMNAMAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885716-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006125803-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | disclosed |