Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522637 | 1.00 | HSD11B1 (0.48) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4527076 | 0.92 | THRB (0.56) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4513802 | 0.87 | HTR6 (0.53) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4519556 | 0.86 | HTR6 (0.48) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4520356 | 0.86 | HTR6 (0.52) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4524885 | 0.85 | HSD11B1 (0.52) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4522172 | 0.84 | GAA (0.56) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4514313 | 0.84 | ADRA1A (0.51) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4511657 | 0.84 | THRB (0.53) | HSD11B1HSD17B2HTR6QRFPRLMNA | |
| SCHEMBL4512103 | 0.83 | HSD11B1 (0.52) | HSD11B1HSD17B2HTR6QRFPRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888518-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126938-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |