Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964263 | 0.95 | HSP90AA1 (0.44) | KDM4EALDH1A1MAPTHSP90AA1HTT | |
| SCHEMBL4961660 | 0.93 | PPARG (0.45) | KDM4EALDH1A1NPSR1 | |
| SCHEMBL4964264 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1HTR2A | |
| SCHEMBL4961989 | 0.85 | ALDH1A1 (0.50) | KDM4EALDH1A1MEN1KMT2AACHE | |
| SCHEMBL4964280 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HTR2A | |
| SCHEMBL4964423 | 0.78 | HTR2A (0.42) | MAPTHTTHTR2A | |
| SCHEMBL4964260 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1MEN1KMT2AACHE | |
| SCHEMBL6443725 | 0.76 | SIGMAR1 (0.44) | ALDH1A1MAPTHSP90AA1HTTNPSR1 | |
| SCHEMBL4965190 | 0.75 | HTR2A (0.43) | ALDH1A1MAPTHTR2A | |
| SCHEMBL4963522 | 0.74 | PPARG (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517679-B1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2008-02-13 | — | — | EP | disclosed |