Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964263 | 0.81 | HSP90AA1 (0.44) | HSP90AA1MAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL4961998 | 0.76 | KDM4E (0.43) | HSP90AA1MAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL4961660 | 0.74 | PPARG (0.45) | NPSR1ALDH1A1CYP2C9PPARG | |
| SCHEMBL3963763 | 0.70 | PPARA (0.45) | PPARG | |
| SCHEMBL4964264 | 0.67 | KDM4E (0.41) | ALDH1A1PPARG | |
| SCHEMBL9321710 | 0.67 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1SMN1; SMN2PTGESALOX5 | |
| SCHEMBL9321708 | 0.67 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1SMN1; SMN2PTGESALOX5 | |
| SCHEMBL4964423 | 0.67 | HTR2A (0.42) | MAPTHTT | |
| SCHEMBL9321687 | 0.66 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL9320258 | 0.66 | SIGMAR1 (0.50) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517679-A1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | AstraZeneca AB (SE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000294-A1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2003-12-31 | — | — | WO | disclosed |