Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.69 |
| ▸ | THRA | P10827 | 16/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147737 | 0.83 | THRB (0.74) | THRBTHRAPTPN1ESR1ESR2 | |
| SCHEMBL10274395 | 0.82 | THRB (1.00) | THRBTHRAPTPN1ESR1ESR2 | |
| SCHEMBL282702 | 0.80 | THRA (0.69) | THRBTHRAPTPN1 | |
| SCHEMBL282128 | 0.79 | THRB (0.79) | THRBTHRAPTPN1 | |
| SCHEMBL328325 | 0.79 | THRB (1.00) | THRBTHRAPTPN1ESR1ESR2 | |
| SCHEMBL328535 | 0.79 | THRB (0.67) | THRBTHRAPTPN1 | |
| SCHEMBL283501 | 0.78 | THRB (0.69) | THRBTHRAPTPN1 | |
| Mb07344 SCHEMBL282003 | 0.77 | THRB (1.00) | THRBTHRA | |
| SCHEMBL21565925 | 0.77 | THRB (0.76) | THRBTHRAPTPN1 | |
| SCHEMBL282663 | 0.77 | THRB (0.76) | THRBTHRAPTPN1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |