Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28883226 | 0.84 | KMT2A (0.38) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL17717276 | 0.80 | KMT2A (0.44) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL29528616 | 0.79 | MEN1 (0.35) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL29528876 | 0.77 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL4963518 | 0.77 | GABRA5 (0.47) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL4911470 | 0.74 | KMT2A (0.39) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL13447331 | 0.74 | IKBKB (0.43) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL13412495 | 0.74 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL5988033 | 0.73 | SMN1; SMN2 (0.49) | MEN1KMT2AALDH1A1GABRA5GABRB2 | |
| SCHEMBL2745279 | 0.73 | GABRA5 (0.46) | MEN1KMT2AALDH1A1GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |