SCHEMBL4963646

SCHEMBL4963646

COc1ccc(-c2ccccc2C(N)=O)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.65
POLB P06746 1/20 0.57
GAA P10253 1/20 0.57
FGFR1 P11362 1/20 0.57
SRC P12931 1/20 0.57
FGFR2 P21802 1/20 0.57
FGFR4 P22455 1/20 0.57
FGFR3 P22607 1/20 0.57
PARP1 P09874 6/20 0.57
SMN1; SMN2 Q16637 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
TUBB4A P04350 1/20 0.53
TUBB P07437 1/20 0.53
TUBA3C P0DPH7 1/20 0.53
TUBA1B P68363 1/20 0.53
TUBA4A P68366 1/20 0.53
TUBB4B P68371 1/20 0.53
TUBB3 Q13509 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29011848 0.86 GAA (0.60) POLBGAAFGFR1SRCFGFR2
SCHEMBL30045516 0.86 GAA (0.60) POLBGAAFGFR1SRCFGFR2
SCHEMBL27779618 0.85 HDAC4 (0.58) BCAT2POLBGAAFGFR1SRC
SCHEMBL5878337 0.85 BCAT2 (0.87) BCAT2PARP1SMN1; SMN2KDM4EMEN1
SCHEMBL28187515 0.85 BCAT2 (0.58) BCAT2POLBGAAFGFR1SRC
SCHEMBL1515687 0.84 GAA (0.63) POLBGAAFGFR1SRCFGFR2
SCHEMBL269580 0.84 SMN1; SMN2 (0.70) POLBGAASMN1; SMN2HDAC4HDAC2
SCHEMBL30582476 0.83 BCAT2 (0.83) BCAT2SMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL1180921 0.83 ABL1 (0.51) BCAT2POLBGAAFGFR1SRC
SCHEMBL6276231 0.83 SLC6A3 (0.71) POLBGAASMN1; SMN2HDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003047572-A1 USE OF 1-PHENYL-OXAZOLIDINE-2-ONE COMPOUNDS AS PROTEASE M INHIBITORS MERCK PATENT GMBH (DE) 2003-06-12 WO claimed
EP-1100505-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR AstraZeneca AB (SE) 2001-05-23 EP claimed
WO-2000000200-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR ASTRAZENECA AB (SE) 2000-01-06 WO claimed
WO-2025109097-A2 NOVEL NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND USES THEREOF HEIDELBERG PHARMA RESEARCH GMBH (DE) 2025-05-30 WO disclosed
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-04-25 US disclosed
CN-115057794-B Method for removing methylation of cerium catalytic oxidation amide by visible light induction 桂林理工大学 2023-11-17 CN disclosed
CN-115057794-A Novel method for removing methylation of cerium-induced catalytic oxidation amide by visible light 桂林理工大学 2022-09-16 CN disclosed
WO-2019174279-A1 1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2019-09-19 WO disclosed
CN-109457268-A A kind of method of electro-catalysis benzamide compound synthesis benzoxazoles 福建医科大学 2019-03-12 CN disclosed
CN-109369555-A A kind of method of microwave radiation benzamide compound synthesis benzoxazoles in water phase 福建医科大学 2019-02-22 CN disclosed
CN-107734969-A Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 美国陶氏益农公司 2018-02-23 CN disclosed
WO-2015074123-A1 FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS Novogen ltd (AU) 2015-05-28 WO disclosed
EP-1954670-A2 NUCLEAR RECEPTOR BINDING AGENTS GTX Inc. (US) 2008-08-13 EP disclosed
WO-2007062230-A2 NUCLEAR RECEPTOR BINDING AGENTS GTX, INC. (US) 2007-05-31 WO disclosed
US-6780883-B2 ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTILIPEMIC AGENTS; RESTENOSIS; DIETETICS WARNER-LAMBERT COMPANY 2004-08-24 US disclosed
WO-2003047572-A1 USE OF 1-PHENYL-OXAZOLIDINE-2-ONE COMPOUNDS AS PROTEASE M INHIBITORS MERCK PATENT GMBH (DE) 2003-06-12 WO disclosed
CN-1335849-A Pyrrolopyrimidines as protein kinase inhibitors BASF AG (DE) 2002-02-13 CN disclosed
EP-0127762-B1 CONSTRAINED N-ALKYLAMINO ARYL KETONES AS SENSITIZERS FOR PHOTOPOLYMER COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-22 EP disclosed
US-4535052-A HIGH SPEED PHOTORESISTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-08-13 US disclosed
EP-0127762-A1 Constrained N-alkylamino aryl ketones as sensitizers for photopolymer compositions E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP MGMT, MCL1, FANCF BCAT2 456/4885POLB 232/4885GAA 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.