Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.46 |
| ▸ | THRA | P10827 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642152 | 0.83 | THRB (0.59) | THRBTHRA | |
| SCHEMBL4963674 | 0.77 | THRB (0.53) | THRBTHRARORC | |
| SCHEMBL4963302 | 0.73 | THRB (0.70) | THRBTHRAALDH1A1MEN1KMT2A | |
| SCHEMBL4963142 | 0.71 | THRB (0.65) | THRBTHRA | |
| SCHEMBL7127009 | 0.70 | THRA (0.46) | THRBTHRA | |
| SCHEMBL4963206 | 0.70 | THRB (0.51) | THRBTHRAALDH1A1MEN1KMT2A | |
| SCHEMBL4962115 | 0.69 | THRB (0.55) | THRBTHRARORC | |
| SCHEMBL7062475 | 0.69 | THRB (0.52) | THRBTHRAMEN1KMT2ARORC | |
| SCHEMBL4964591 | 0.68 | THRB (0.51) | THRBTHRAALDH1A1MEN1KMT2A | |
| SCHEMBL4965136 | 0.67 | THRB (0.56) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268404-B1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2008-01-02 | — | — | EP | claimed |