Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RAD52 | P43351 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282560 | 0.81 | KCNH2 (0.36) | L3MBTL1MEN1KMT2ALMNACALM1 | |
| SCHEMBL4201188 | 0.72 | GABRA1 (0.40) | ALOX5GABRA1GABRB2HTTMAPT | |
| SCHEMBL4034974 | 0.71 | GABRA1 (0.42) | ALOX5GABRA1GABRB2HTTMAPT | |
| SCHEMBL4189061 | 0.71 | THRB (0.40) | ALOX5GABRA1GABRB2HTTMAPT | |
| SCHEMBL4185116 | 0.68 | SMN1; SMN2 (0.42) | HTTMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL14586637 | 0.66 | ATM (0.51) | NPC1SMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL4960984 | 0.66 | GABRA1 (0.36) | ALOX5GABRA1GABRB2THRB | |
| SCHEMBL12356976 | 0.65 | AKT1 (0.40) | HTTMAPTMAPK1L3MBTL1KMT2A | |
| SCHEMBL2128468 | 0.65 | GABRA1 (0.38) | ALOX5GABRA1GABRB2MAPK1MEN1 | |
| SCHEMBL28131611 | 0.65 | ALOX5 (0.54) | ALOX5GABRA1GABRB2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |