Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189061 | 0.81 | THRB (0.40) | GABRA1GABRB2ALOX5GABRA5GABRA3 | |
| SCHEMBL281944 | 0.81 | THRB (0.39) | ESR1ESR2SLC5A1SLC5A2THRA | |
| SCHEMBL4960984 | 0.76 | GABRA1 (0.36) | GABRA1GABRB2ALOX5HMGCRGABRA5 | |
| SCHEMBL18020671 | 0.76 | ATM (0.47) | GABRA1GABRB2ESR1ESR2MEN1 | |
| SCHEMBL4961165 | 0.74 | HTT (0.45) | ALOX5ESR1THRATHRBMEN1 | |
| SCHEMBL4964744 | 0.72 | ALOX5 (0.34) | GABRA1GABRB2ALOX5THRBMEN1 | |
| SCHEMBL4034974 | 0.72 | GABRA1 (0.42) | GABRA1GABRB2ALOX5THRBMEN1 | |
| SCHEMBL282633 | 0.71 | THRA (0.47) | THRATHRB | |
| SCHEMBL8347901 | 0.70 | ESR1 (0.70) | ESR1ESR2SLC5A1SLC5A2THRA | |
| SCHEMBL14139877 | 0.70 | NPSR1 (0.46) | ALOX5ESR1ESR2HMGCRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |