Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964772 | 0.89 | HRH1 (0.51) | HRH1 | |
| Hydrochloric Acid SCHEMBL4964910 | 0.83 | KIT (0.39) | SLC6A4 | |
| SCHEMBL4964913 | 0.82 | SCN9A (0.37) | HTR2BHRH1 | |
| SCHEMBL4964731 | 0.78 | KIT (0.42) | SLC6A4SLC6A2SLC6A3HRH1 | |
| SCHEMBL4966050 | 0.76 | GABRA1 (0.38) | SLC6A4HTR1ASLC6A2SLC6A3HRH1 | |
| SCHEMBL4964287 | 0.74 | HRH1 (0.43) | SLC6A4HRH1 | |
| SCHEMBL4963979 | 0.73 | IDH1 (0.44) | — | |
| SCHEMBL4963958 | 0.73 | HRH1 (0.49) | HRH1 | |
| SCHEMBL4966480 | 0.71 | TAAR1 (0.46) | SLC6A4HTR6HTR2CHTR1ASLC6A2 | |
| SCHEMBL4966731 | 0.68 | TAAR1 (0.41) | HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |