Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966731 | 0.76 | TAAR1 (0.41) | PTPN1PTPN2PTPN6 | |
| SCHEMBL4966480 | 0.74 | TAAR1 (0.46) | — | |
| SCHEMBL4964869 | 0.73 | SLC6A4 (0.41) | — | |
| SCHEMBL4964287 | 0.73 | HRH1 (0.43) | — | |
| SCHEMBL4966050 | 0.72 | GABRA1 (0.38) | — | |
| SCHEMBL4963958 | 0.72 | HRH1 (0.49) | — | |
| SCHEMBL4964772 | 0.72 | HRH1 (0.51) | — | |
| Hydrochloric Acid SCHEMBL4964910 | 0.71 | KIT (0.39) | DAO | |
| SCHEMBL6230711 | 0.69 | MEN1 (0.37) | PARP1DAOALOX5 | |
| SCHEMBL278794 | 0.67 | IDH1 (0.65) | IDH1HNF4ABCL2BCL2L1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |