Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 8/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967183 | 0.91 | HTR2C (0.46) | TAAR1HTR6DPP4HTR1ASLC6A2 | |
| SCHEMBL4963734 | 0.77 | ADRB1 (0.38) | HTR6HTR1ANCF1KDRHTR3A | |
| SCHEMBL4963979 | 0.74 | IDH1 (0.44) | — | |
| SCHEMBL4964772 | 0.74 | HRH1 (0.51) | — | |
| SCHEMBL4966050 | 0.72 | GABRA1 (0.38) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4964869 | 0.71 | SLC6A4 (0.41) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4964731 | 0.68 | KIT (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4966731 | 0.68 | TAAR1 (0.41) | TAAR1HTR6HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL4964910 | 0.68 | KIT (0.39) | SLC6A4 | |
| SCHEMBL6164646 | 0.66 | HTR1A (0.60) | TAAR1HTR6HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |