Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201656 | 0.89 | ADRA1A (0.46) | ACLYADRA1AHTR6QRFPRDRD2 | |
| SCHEMBL4214386 | 0.78 | HTR6 (0.52) | ACLYHTR6QRFPRDRD2DRD3 | |
| SCHEMBL4201083 | 0.77 | DRD2 (0.42) | ACLYHTR6QRFPRDRD2DRD3 | |
| SCHEMBL4209430 | 0.77 | HTR6 (0.42) | ACLYHTR6QRFPRDRD2DRD3 | |
| SCHEMBL4211776 | 0.76 | CA1 (0.41) | ACLYHTR6QRFPR | |
| SCHEMBL4209428 | 0.74 | PPARG (0.40) | ACLYHTR6QRFPRDRD2DRD3 | |
| SCHEMBL13942853 | 0.73 | HTR6 (0.41) | ACLYHTR6QRFPRDRD2DRD3 | |
| SCHEMBL13942868 | 0.72 | CACNB4 (0.41) | ACLYHTR6QRFPR | |
| SCHEMBL4199329 | 0.72 | HTR6 (0.48) | ACLYADRA1AHTR6QRFPRDRD2 | |
| SCHEMBL4966544 | 0.68 | HTR6 (0.74) | ADRA1AHTR6QRFPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |