Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 8/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CASP9 | P55211 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2380306 | 0.71 | MAPK14 (0.49) | LRRK2GRM5ABL1 | |
| SCHEMBL30364024 | 0.70 | SMYD3 (0.57) | TDP2SMYD3GRM5AHRCASP3 | |
| SCHEMBL9376495 | 0.70 | SMYD3 (0.57) | TDP2SMYD3GRM5AHRCASP3 | |
| SCHEMBL4960140 | 0.69 | PI4K2A (0.46) | CHEK1ABL1 | |
| SCHEMBL10714481 | 0.68 | TDP2 (0.53) | LRRK2TDP2BRD4CREBBPSMYD3 | |
| SCHEMBL6588159 | 0.67 | IKBKB (0.51) | — | |
| SCHEMBL10712665 | 0.66 | AHR (0.56) | LRRK2TDP2BRD4CREBBPCHEK1 | |
| SCHEMBL29849951 | 0.66 | CRBN (0.51) | LRRK2TDP2BRD4CREBBPCHEK1 | |
| SCHEMBL15775800 | 0.66 | ACMSD (0.46) | — | |
| SCHEMBL31116938 | 0.66 | AHR (0.60) | TDP2BRD4CREBBPGRM5AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896461-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | Amgen Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005668-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-01-11 | — | — | WO | disclosed |