Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 9/20 | 0.44 |
| ▸ | CHUK | O15111 | 8/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965915 | 0.77 | GSK3B (0.47) | RIPK2LCKBTKCHEK1KDM4E | |
| SCHEMBL29018616 | 0.73 | HDAC6 (0.39) | PI4K2AIKBKBCHUKCHEK1ALDH1A1 | |
| SCHEMBL27682000 | 0.72 | LCK (0.56) | PI4K2AIKBKBCHUKRIPK2LCK | |
| SCHEMBL28136345 | 0.72 | LCK (0.56) | PI4K2AIKBKBCHUKRIPK2LCK | |
| SCHEMBL30369932 | 0.72 | LCK (0.56) | PI4K2AIKBKBCHUKRIPK2LCK | |
| SCHEMBL2564058 | 0.72 | ROCK2 (0.50) | RIPK2LCKBTKCHEK1KDM4E | |
| SCHEMBL3663816 | 0.72 | CCNT1 (0.58) | PI4K2AIKBKBCHUKRIPK2LCK | |
| SCHEMBL1828299 | 0.70 | PI4K2A (0.50) | PI4K2AIKBKBCHUKRIPK2LCK | |
| SCHEMBL15775800 | 0.70 | ACMSD (0.46) | LCKKDM4E | |
| SCHEMBL29437284 | 0.69 | PI4K2A (0.55) | PI4K2AIKBKBCHUKRIPK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896461-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | Amgen Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005668-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-01-11 | — | — | WO | disclosed |