Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.52 |
| ▸ | FLT3 | P36888 | 8/20 | 0.52 |
| ▸ | CSF1R | P07333 | 7/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.52 |
| ▸ | FLT1 | P17948 | 7/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.52 |
| ▸ | FLT4 | P35916 | 6/20 | 0.52 |
| ▸ | PLK4 | O00444 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 6/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 6/20 | 0.52 |
| ▸ | LYN | P07948 | 6/20 | 0.52 |
| ▸ | BLK | P51451 | 6/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.52 |
| ▸ | STK3 | Q13188 | 6/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 6/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966755 | 0.82 | NPC1 (0.50) | KDRMEN1KMT2ASMN1; SMN2CASP3 | |
| SCHEMBL4964671 | 0.81 | KDR (0.55) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL4966551 | 0.78 | RIPK1 (0.56) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL15626839 | 0.76 | KDR (0.53) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL19048693 | 0.69 | KDR (0.62) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL4486611 | 0.68 | KDR (1.00) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL3530946 | 0.68 | KDR (1.00) | KDRFLT3CSF1RFGFR1FLT1 | |
| SCHEMBL5359926 | 0.67 | SMN1; SMN2 (0.77) | CLK4ROCK2KMT2ATP53EPHX1 | |
| SCHEMBL11059378 | 0.67 | SMN1; SMN2 (0.94) | CLK4MEN1LMNAKMT2ATP53 | |
| SCHEMBL15626697 | 0.67 | ALDH1A1 (0.47) | KDRLCKPRKCZMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | claimed |