Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.55 |
| ▸ | FLT3 | P36888 | 5/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | PLK4 | O00444 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 3/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.55 |
| ▸ | BLK | P51451 | 3/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.55 |
| ▸ | STK3 | Q13188 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.55 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19048693 | 0.88 | KDR (0.62) | KDRFLT3CLK4CSF1RFGFR1 | |
| SCHEMBL2368807 | 0.84 | ALDH1A1 (0.67) | PRKCIPRKCZALDH1A1HPGDMEN1 | |
| SCHEMBL4962368 | 0.81 | NPC1 (0.53) | KDRPRKCZMEN1KMT2AMAPT | |
| SCHEMBL4965360 | 0.81 | KDR (0.52) | KDRFLT3CLK4CSF1RFGFR1 | |
| SCHEMBL15626839 | 0.79 | KDR (0.53) | KDRFLT3CLK4CSF1RFGFR1 | |
| SCHEMBL4962826 | 0.78 | PRKCZ (0.61) | PRKCIPRKCZALDH1A1HPGDMEN1 | |
| SCHEMBL4964462 | 0.77 | KIT (0.64) | KDRFLT3CLK4CSF1RFGFR1 | |
| SCHEMBL4964795 | 0.77 | RIPK1 (0.58) | KDRFLT3CLK4CSF1RFGFR1 | |
| SCHEMBL8188234 | 0.73 | KMT2A (0.65) | PRKCIPRKCZALDH1A1HPGDMEN1 | |
| SCHEMBL1799330 | 0.73 | KMT2A (0.69) | PRKCZALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436279-B8 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | claimed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | claimed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | claimed |
| EP-1436279-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | claimed |
| US-20040192941-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | claimed |
| EP-1436279-A1 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003027093-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | claimed |
| EP-1436279-B8 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | disclosed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1436279-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20040192941-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | disclosed |
| EP-1436279-A1 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003027093-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192941-A1 | Chemical compounds | TPMT, TST, CYP11B2 | KDR 3563/4885FLT3 1141/4885CLK4 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.