Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963059 | 0.87 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1LMNAPKM | |
| SCHEMBL4962685 | 0.85 | MEN1 (0.60) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4965824 | 0.84 | KMT2A (0.51) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL4963943 | 0.84 | KDM4E (0.47) | ALDH1A1LMNAHTTSMN1; SMN2KDM1A | |
| SCHEMBL4966790 | 0.83 | KDM1A (0.45) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4964738 | 0.83 | KMT2A (0.50) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL4963112 | 0.83 | KMO (0.55) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4973290 | 0.83 | TSHR (0.45) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4964673 | 0.82 | KDM1A (0.53) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4963200 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |