Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.53 |
| ▸ | MAOA | P21397 | 6/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966790 | 0.87 | KDM1A (0.45) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4966051 | 0.84 | KDM1A (0.60) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4964018 | 0.84 | ALDH1A1 (0.47) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4962685 | 0.84 | MEN1 (0.60) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4965945 | 0.83 | GLO1 (0.48) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4964152 | 0.83 | CA1 (0.40) | KDM1AMAOAHSD17B2MEN1KMT2A | |
| SCHEMBL4965545 | 0.82 | KMT2A (0.46) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4966328 | 0.82 | CA1 (0.44) | KDM1AMAOAHSD17B2MEN1KMT2A | |
| SCHEMBL4965281 | 0.82 | MEN1 (0.64) | KDM1AMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL4964537 | 0.81 | MEN1 (0.43) | KDM1AMAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |