Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963210 | 0.98 | TRPV4 (0.40) | TRPV4HSD11B1NMT1CNR1CNR2 | |
| SCHEMBL4965593 | 0.92 | NMT1 (0.44) | TRPV4HSD11B1NMT1CNR1CNR2 | |
| SCHEMBL4964100 | 0.90 | NMT1 (0.47) | TRPV4HSD11B1NMT1CNR1CNR2 | |
| SCHEMBL4964132 | 0.87 | ROCK1 (0.42) | TRPV4LMNATSHRALDH1A1SIGMAR1 | |
| SCHEMBL4965583 | 0.84 | NPC1 (0.43) | TRPV4HSD11B1ALDH1A1UBE2NMEN1 | |
| SCHEMBL4966824 | 0.79 | NPC1 (0.42) | TRPV4HSD11B1LMNATSHRALDH1A1 | |
| SCHEMBL4966984 | 0.78 | HDAC3 (0.48) | LMNATSHRALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4964824 | 0.77 | EPHX2 (0.49) | TRPV4TSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4963626 | 0.76 | KMT2A (0.48) | HSD11B1LMNAHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL4962705 | 0.76 | HSD11B1 (0.42) | HSD11B1NMT1HSD17B1HSD17B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |