Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.38 |
| ▸ | THRB | P10828 | 7/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189061 | 0.82 | THRB (0.40) | THRATHRBALOX5OPRK1OPRM1 | |
| SCHEMBL282233 | 0.80 | THRB (0.45) | THRATHRBOPRK1 | |
| SCHEMBL4961165 | 0.75 | HTT (0.45) | THRATHRBALOX5OPRK1OPRM1 | |
| SCHEMBL282633 | 0.74 | THRA (0.47) | THRATHRBOPRK1OPRM1OPRD1 | |
| SCHEMBL282289 | 0.70 | THRA (0.42) | THRATHRBOPRK1OPRM1OPRD1 | |
| SCHEMBL282611 | 0.70 | THRA (0.48) | THRATHRBOPRK1OPRM1OPRD1 | |
| SCHEMBL282562 | 0.70 | THRB (0.50) | THRATHRB | |
| SCHEMBL282333 | 0.69 | CALM1 (0.45) | THRATHRBOPRK1OPRM1OPRD1 | |
| SCHEMBL282460 | 0.69 | OPRK1 (0.48) | THRATHRBOPRK1OPRM1OPRD1 | |
| SCHEMBL3155899 | 0.68 | OPRK1 (0.39) | THRATHRBOPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |