Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.68 |
| ▸ | IAPP | P10997 | 3/20 | 0.57 |
| ▸ | YWHAG | P61981 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894924 | 0.91 | APP (0.57) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL3274537 | 0.82 | APP (0.68) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL7568170 | 0.81 | APP (1.00) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL925636 | 0.79 | IAPP (0.62) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL30986806 | 0.79 | IAPP (0.62) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL5606900 | 0.79 | ESR1 (0.50) | APPCYP19A1KDM4EMAPTTDP1 | |
| SCHEMBL29116446 | 0.79 | APP (0.64) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL30291871 | 0.79 | APP (0.73) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL22353624 | 0.79 | APP (0.84) | APPIAPPYWHAGCYP19A1TYR | |
| SCHEMBL490911 | 0.79 | APP (0.73) | APPIAPPYWHAGCYP19A1TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959948-A2 | LEVODOPA PRODRUG MESYLATE, COMPOSITIONS THEREOF, AND USES THEREOF | Xenoport, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067495-A2 | LEVODOPA PRODRUG MESYLATE, COMPOSITIONS THEREOF, AND USES THEREOF | XENOPORT, INC. (US) | 2007-06-14 | — | — | WO | disclosed |