Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963719 | 1.00 | MEN1 (0.45) | MEN1KMT2AHDAC1HRH3POLB | |
| SCHEMBL4968562 | 0.86 | HDAC6 (0.45) | MEN1KMT2AHDAC1MCHR1ALDH1A1 | |
| SCHEMBL4966804 | 0.84 | HDAC1 (0.52) | MEN1KMT2AHDAC1HRH3POLB | |
| SCHEMBL4964378 | 0.84 | HDAC1 (0.52) | MEN1KMT2AHDAC1HRH3POLB | |
| SCHEMBL4966598 | 0.82 | MCHR1 (0.41) | MEN1KMT2APOLBMCHR1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4966249 | 0.81 | HDAC6 (0.40) | HDAC1POLBALDH1A1KDM4ESLC8A1 | |
| SCHEMBL4971525 | 0.77 | OPRM1 (0.40) | MEN1KMT2AHDAC1POLBALDH1A1 | |
| SCHEMBL4968023 | 0.77 | OPRM1 (0.46) | POLBMCHR1NPC1RAB9A | |
| SCHEMBL4965638 | 0.76 | OPRM1 (0.41) | HDAC1HRH3SMN1; SMN2 | |
| SCHEMBL4965646 | 0.76 | OPRM1 (0.41) | MEN1KMT2AHDAC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |