Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963457 | 0.99 | SLC2A1 (0.42) | OPRM1OPRD1OPRK1SLC2A1HRH4 | |
| SCHEMBL4967478 | 0.89 | KDM4E (0.49) | SLC2A1SMN1; SMN2LMNA | |
| SCHEMBL4965138 | 0.89 | MCHR1 (0.43) | SLC2A1SMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL4966629 | 0.88 | SLC2A1 (0.37) | OPRM1OPRD1OPRK1SLC2A1S1PR1 | |
| SCHEMBL4966256 | 0.86 | AURKA (0.35) | SLC2A1SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4965633 | 0.86 | OPRM1 (0.45) | OPRM1OPRD1OPRK1S1PR1S1PR3 | |
| SCHEMBL4965646 | 0.85 | OPRM1 (0.41) | OPRM1OPRD1OPRK1SLC2A1SMN1; SMN2 | |
| SCHEMBL4965252 | 0.85 | OPRM1 (0.41) | OPRM1OPRD1OPRK1SLC2A1 | |
| Hydrochloric Acid SCHEMBL4965277 | 0.84 | OPRM1 (0.41) | OPRM1OPRD1OPRK1SMN1; SMN2CYP2D6 | |
| SCHEMBL4964364 | 0.84 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |