Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966598 | 0.92 | MCHR1 (0.41) | OPRM1OPRK1OPRD1MCHR1RAB9A | |
| SCHEMBL4965903 | 0.85 | OPRM1 (0.61) | OPRM1OPRK1OPRD1MCHR1RAB9A | |
| SCHEMBL4968054 | 0.83 | PARP1 (0.43) | POLBMAPT | |
| SCHEMBL4968562 | 0.82 | HDAC6 (0.45) | OPRM1OPRK1OPRD1MCHR1ITGB3 | |
| SCHEMBL4965252 | 0.82 | OPRM1 (0.41) | OPRM1OPRK1OPRD1MCHR1RAB9A | |
| SCHEMBL5668119 | 0.82 | OPRM1 (0.53) | OPRM1OPRK1OPRD1MCHR1RAB9A | |
| SCHEMBL4966564 | 0.81 | MEN1 (0.44) | POLBMAPTKCNH2 | |
| SCHEMBL4965638 | 0.80 | OPRM1 (0.41) | OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL4965646 | 0.80 | OPRM1 (0.41) | OPRM1OPRK1OPRD1RAB9ANPC1 | |
| SCHEMBL4967478 | 0.80 | KDM4E (0.49) | MCHR1RAB9ANPC1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |