SCHEMBL4966384

SCHEMBL4966384

CNCCN(C)NC(N)=O

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PRMT3 O60678 1/20 0.42
CARM1 Q86X55 1/20 0.42
PRMT6 Q96LA8 1/20 0.42
PRMT1 Q99873 1/20 0.42
PRMT8 Q9NR22 1/20 0.42
PLAU P00749 1/20 0.32
KDM4A O75164 1/20 0.30
KDM4C Q9H3R0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15131278 0.84 LMNA (0.33)
SCHEMBL12286330 0.73
SCHEMBL2702523 0.72 MAPT (0.33)
SCHEMBL27968686 0.72
SCHEMBL144324 0.70 PRMT3 (0.42) PRMT3CARM1PRMT6PRMT1PRMT8
SCHEMBL28214730 0.69 KDM4A (0.34) KDM4AKDM4C
SCHEMBL27949920 0.69
SCHEMBL28003253 0.68 KDM7A (0.37)
SCHEMBL29286224 0.68 CHRNB2 (0.42) PRMT3CARM1PRMT6PRMT1PRMT8
SCHEMBL7887973 0.68 PRMT3 (0.58) PRMT3CARM1PRMT6PRMT1PRMT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008033475-A2 ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS ONCONOVA THERAPEUTICS, INC. (US) 2008-03-20 WO disclosed