Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972027 | 0.92 | MAPT (0.46) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4972329 | 0.88 | KDM4E (0.42) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4968337 | 0.88 | MAPT (0.44) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4970200 | 0.87 | MAPT (0.43) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4971672 | 0.83 | HTR6 (0.43) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4969062 | 0.82 | KDM4E (0.43) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4970261 | 0.80 | KDM4E (0.42) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4968166 | 0.79 | KDM4E (0.40) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4970757 | 0.78 | KDM4E (0.41) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL4971454 | 0.74 | HTR6 (0.41) | KDM4EMAPTALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |