Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972027 | 0.89 | MAPT (0.46) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4966957 | 0.87 | KDM4E (0.45) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4970766 | 0.86 | HTR6 (0.42) | MAPTKDM4EALDH1A1LMNAHTR6 | |
| SCHEMBL4972329 | 0.85 | KDM4E (0.42) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4968337 | 0.84 | MAPT (0.44) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4970757 | 0.81 | KDM4E (0.41) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4971672 | 0.80 | HTR6 (0.43) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL13665494 | 0.80 | USP14 (0.38) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4969062 | 0.77 | KDM4E (0.43) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL13665753 | 0.77 | SLC6A4 (0.40) | MAPTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |