Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972329 | 0.92 | KDM4E (0.42) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4966957 | 0.92 | KDM4E (0.45) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4968337 | 0.92 | MAPT (0.44) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4971672 | 0.90 | HTR6 (0.43) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4970200 | 0.89 | MAPT (0.43) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4970261 | 0.84 | KDM4E (0.42) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4969062 | 0.82 | KDM4E (0.43) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4970757 | 0.79 | KDM4E (0.41) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4968166 | 0.78 | KDM4E (0.40) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL4971454 | 0.78 | HTR6 (0.41) | MAPTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |