Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967813 | 0.86 | KMT2A (0.70) | PFKFB3KMT2APOLBCA12CA2 | |
| SCHEMBL12368208 | 0.81 | KMT2A (0.67) | PFKFB3KMT2APOLBCYP3A4CYP2D6 | |
| SCHEMBL788132 | 0.81 | PFKFB3 (0.59) | PFKFB3KMT2APOLBEDNRAPIK3CB | |
| SCHEMBL926620 | 0.77 | AAK1 (0.57) | KMT2ANPC1CYP3A4MEN1LMNA | |
| SCHEMBL787794 | 0.75 | PKM (0.61) | PFKFB3KMT2APOLBEDNRAPFKFB4 | |
| SCHEMBL794101 | 0.75 | PFKFB3 (0.69) | PFKFB3KMT2APOLBEDNRAPFKFB4 | |
| SCHEMBL21857663 | 0.75 | PFKFB3 (1.00) | PFKFB3KMT2APOLBPFKFB4 | |
| SCHEMBL7804115 | 0.75 | CA2 (0.59) | PFKFB3KMT2ANPC1CA12CA2 | |
| SCHEMBL15063697 | 0.74 | PFKFB3 (0.59) | PFKFB3KMT2APOLBEDNRAPFKFB4 | |
| SCHEMBL788401 | 0.74 | EDNRA (0.53) | PFKFB3KMT2APOLBEDNRAPFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963287-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| US-7348322-B2 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348322-B2 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007065828-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | NR3C1, MC2R, NR3C2 | PFKFB3 3462/4885KMT2A 4322/4885POLB 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.