Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968015 | 0.93 | ALDH1A1 (0.33) | KDM4ELMNAMAPTHPGDHTT | |
| SCHEMBL4970674 | 0.92 | RAPGEF4 (0.34) | KDM4ELMNAMAPTHPGDHTT | |
| Hydrochloric Acid SCHEMBL3671010 | 0.89 | NOS1 (0.33) | BACE1 | |
| Hydrochloric Acid SCHEMBL821776 | 0.87 | KDM4E (0.31) | KDM4ELMNAMAPTHPGDHTT | |
| SCHEMBL16653951 | 0.86 | NOS1 (0.35) | BACE1 | |
| SCHEMBL23535362 | 0.85 | NOS1 (0.34) | BACE1 | |
| SCHEMBL14830125 | 0.85 | NOS1 (0.34) | BACE1 | |
| Hydrochloric Acid SCHEMBL39685 | 0.85 | BACE1 (0.34) | BACE1 | |
| SCHEMBL20703459 | 0.83 | NOS1 (0.35) | BACE1 | |
| SCHEMBL25439645 | 0.83 | NOS1 (0.33) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3058002-A1 | POLYETHYLENE OF RAISED TEMPERATURE RESISTANCE | Basell Polyolefine GmbH (DE) | 2016-08-24 | — | — | EP | disclosed |
| EP-3058026-A1 | POLYETHYLENE FOR INJECTION MOULDING | Basell Polyolefine GmbH (DE) | 2016-08-24 | — | — | EP | disclosed |
| EP-3058025-A1 | POLYETHYLENE COMPOSITION FOR INJECTION MOULDING | Basell Polyolefine GmbH (DE) | 2016-08-24 | — | — | EP | disclosed |
| EP-2935414-A1 | POLYETHYLENE COMPOSITION HAVING HIGH MECHANICAL PROPERTIES | Basell Polyolefine GmbH (DE) | 2015-10-28 | — | — | EP | disclosed |
| WO-2015055393-A1 | POLYETHYLENE FOR INJECTION MOULDING | BASELL POLYOLEFINE GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015055394-A1 | POLYETHYLENE COMPOSITION FOR INJECTION MOULDING | BASELL POLYOLEFINE GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015055392-A1 | POLYETHYLENE OF RAISED TEMPERATURE RESISTANCE | BASELL POLYOLEFINE GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| WO-2014095231-A1 | POLYETHYLENE COMPOSITION HAVING HIGH MECHANICAL PROPERTIES | BASELL POLYOLEFINE GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| EP-2563957-A2 | POLYMER FILAMENT OR FIBER | Basell Polyolefine GmbH (DE) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134897-A2 | POLYMER FILAMENT OR FIBER | BASELL POLYOLEFINE GMBH (DE) | 2011-11-03 | — | — | WO | disclosed |