Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.47 |
| ▸ | XPO1 | O14980 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | ATF1 | P18846 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969158 | 0.90 | KCNQ3 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1GRM4 | |
| SCHEMBL4969767 | 0.88 | GRM4 (0.59) | GRM4TMPRSS4BRAF | |
| SCHEMBL4966413 | 0.86 | BRAF (0.47) | KCNQ3KCNQ2KCNE1KCNQ1GRM4 | |
| SCHEMBL4966684 | 0.84 | NFKB1 (0.58) | KCNQ3KCNQ2KCNE1KCNQ1TMPRSS4 | |
| SCHEMBL4970352 | 0.82 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL4967737 | 0.81 | P2RX1 (0.58) | KCNQ3KCNQ2KCNE1KCNQ1TMPRSS4 | |
| SCHEMBL4970824 | 0.80 | P2RX1 (0.54) | ABL1 | |
| SCHEMBL4969220 | 0.79 | NFKB1 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1TMPRSS4 | |
| SCHEMBL4971162 | 0.78 | RAB9A (0.51) | NFKB1NFKB2RELA | |
| SCHEMBL4967520 | 0.78 | RAB9A (0.53) | KCNQ3KCNQ2KCNE1KCNQ1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247556-B2 | Method for preparing 6-substituted-7-aza-indoles | AMGEN INC. (US) | 2012-08-21 | — | — | US | disclosed |
| EP-1971604-B1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| US-20070185171-A1 | Compounds and methods of use | AMGEN INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185171-A1 | Compounds and methods of use | VHL, PGF, PTGIS | KCNQ3 3613/4885KCNQ2 3979/4885KCNE1 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.