Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10172985 | 0.86 | CYP19A1 (0.58) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3588993 | 0.81 | GRIA1 (0.60) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5150341 | 0.79 | MAPT (0.51) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1630724 | 0.79 | MAPT (0.51) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4427396 | 0.76 | GRIA1 (0.58) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL11997383 | 0.76 | CYP2A6 (0.51) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL397992 | 0.76 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4885975 | 0.75 | MAPT (0.47) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9053698 | 0.75 | NPBWR1 (0.52) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7257404 | 0.75 | GRIA1 (0.60) | MAPTGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-A2 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | Eli Lilly & Company (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007087488-A9 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2008-08-28 | — | — | WO | disclosed |
| WO-2007087488-A2 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |