Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CTSV | O60911 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881078 | 0.87 | MAPKAPK2 (0.52) | MAPKAPK2MAOBMAOAMEN1HSP90AA1 | |
| SCHEMBL6610802 | 0.83 | BAZ2B (0.52) | MAPKAPK2HSD17B10CYP1A2CYP2C9LMNA | |
| SCHEMBL4969326 | 0.80 | MAPT (0.43) | KDM4EHPGDHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL8316102 | 0.76 | MAPKAPK2 (0.55) | MAPKAPK2MAOBMAOACTSVCTSL | |
| SCHEMBL8316089 | 0.76 | MAPKAPK2 (0.55) | MAPKAPK2MAOBMAOAMEN1KMT2A | |
| SCHEMBL7666158 | 0.74 | MAPKAPK2 (0.59) | MAPKAPK2MAOBMAOACTSVCTSL | |
| SCHEMBL8228026 | 0.74 | BAZ2B (0.57) | MAPKAPK2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL25634129 | 0.74 | MCHR1 (0.61) | MAPKAPK2MAOBMAOAKMT2ACTSV | |
| SCHEMBL31153237 | 0.74 | MCHR1 (0.61) | MAPKAPK2MAOBMAOAKMT2ACTSV | |
| SCHEMBL2978779 | 0.73 | LMNA (0.63) | MAPKAPK2MAOBMAOAKMT2ACTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453803-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | Zentaris GmbH (DE) | 2004-09-08 | — | — | EP | claimed |
| WO-2003051837-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | ZENTARIS GMBH (DE) | 2003-06-26 | — | — | WO | claimed |