Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965996 | 0.90 | TP53 (0.37) | EPHX2POLBKMT2AMEN1HDAC4 | |
| SCHEMBL4967217 | 0.85 | IMPDH2 (0.46) | EPHX2POLBKMT2AMEN1HDAC4 | |
| SCHEMBL981548 | 0.83 | EPHX2 (0.40) | EPHX2HDAC4NPC1MAPTRAB9A | |
| SCHEMBL986328 | 0.83 | NR3C1 (0.40) | EPHX2POLBKMT2AMEN1 | |
| SCHEMBL4966906 | 0.80 | EPHX2 (0.33) | EPHX2POLBKMT2AMEN1HDAC4 | |
| SCHEMBL4966914 | 0.80 | EPHX2 (0.33) | EPHX2POLBKMT2AMEN1HDAC4 | |
| SCHEMBL14493794 | 0.76 | RHOA (0.43) | EPHX2NAMPT | |
| SCHEMBL4967016 | 0.72 | BDKRB1 (0.31) | EPHX2HDAC4BDKRB1 | |
| SCHEMBL4967009 | 0.72 | BDKRB1 (0.31) | EPHX2HDAC4BDKRB1 | |
| SCHEMBL984225 | 0.72 | HDAC4 (0.49) | EPHX2POLBKMT2AMEN1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963287-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | claimed |
| US-7348322-B2 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | claimed |
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | claimed |
| WO-2007065828-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | NR3C1, MC2R, NR3C2 | EPHX2 1311/4885POLB 4531/4885KMT2A 4322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.