Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924493 | 0.77 | BACE1 (0.44) | BACE1CYP3A4CYP2C9 | |
| SCHEMBL924407 | 0.77 | BACE1 (0.47) | BACE1CYP3A4CYP2C9 | |
| SCHEMBL925096 | 0.63 | KDM4E (0.41) | BACE1CYP2C9 | |
| SCHEMBL30281248 | 0.62 | CYP11B2 (0.54) | CYP3A4CYP2C9 | |
| SCHEMBL924396 | 0.59 | LMNA (0.39) | — | |
| SCHEMBL21816208 | 0.57 | ALDH1A1 (0.61) | CYP3A4CYP2C9 | |
| SCHEMBL30281205 | 0.57 | ALDH1A1 (0.61) | CYP3A4CYP2C9 | |
| SCHEMBL926212 | 0.57 | HSD17B10 (0.43) | CYP2C9 | |
| SCHEMBL924196 | 0.57 | ALDH1A1 (0.54) | — | |
| SCHEMBL29503151 | 0.55 | DGAT1 (0.53) | CYP2C9SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |